Suzanne de Bruijn

135 A RIPOR2 deletion is a frequent cause of adult-onset hearing loss A NM_0014722 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 NM_01346031 1 2 3 4 5 6 7 8 9 10 11 12 14 NM_01286445 1a 2 3 4 5 6 7 8 9 10 11 12 14 NM_015864 1b 2 3 4 5 6 7 8 9 10 11 12 14 14a NM_01286446 1c 2 3 4 5 6 7 8 9 10 11 12 14 NM_01286447 1b 2 3 4 5 6 7 8 9 10 11 12 14 14b 14b B 15 16 17 18 19 20 21 22 23 15 16 17 18 19 20 21 22 23 Homo sapiens Macaca mulatta Rattus norvegicus Mus musculus Canis lupus fam. Gallus gallus Xenopus tropicalis Danio rerio p.(Gln566_Lys569del) G G G G G G G G S N N N N N N N L I I I I I I I T T T T T T T T R K K K K K K K Q Q Q Q Q Q Q Q L L L L L L L L V V V V V V V V R K K K K K K K R R R R R R R R L L L L L L L L T T T T T T T T S S S S S S S T S A S A A A A A RIPOR2 c.1696_1707del Figure S2. Schematic overview of major RIPOR2 transcripts. (A) Transcripts are extracted from the Ensembl genome browser. The position of the c.1696_1707del RIPOR2 variant is indicated with an arrow. (B) Evolutionary conservation of the amino acids that are affected by the variant. Fully conserved amino acid residues are shown on a black background. A dark grey background marks chemical similarity of residues and a light grey background indicates chemical dissimilarity.