Suzanne de Bruijn

214 Chapter 4 GTCTTTGT----TTCTTCTCTCTCTTTCTTTCTTCCTTTTCTTTCCTTCC ----------TTAG----CCTGCGTGGTGGCGGGCAACTGTAATCCCAGC I-J L-J L-M CAGAGCTGATTTAGTAGGAATGGGTTGGGCCTGAGATCCTGCATTTCTTT CAGAGCTGATTTAGTAGGAATGGGTTGGGCCTGAGATCCTGCATTTCTTT **** ** ** * * * * * * ** * C TTCTCGGGAGACTTAGGCAGGAGAATTGCTTGAACCAGAGAGGCAGAGGT GTCTTTGT----TTCTTCTCTCTCTTTCTTTCTTCCTTTTCTTTCCTTCC *** * ** * ** ** ** TGCAGTGAGCCGAGATCACACCACTGCACTCAAGCCTGGGCAACAAGAGC TTCCTTCGCTTTCTTTCTTTCCTTTTTTT---TTTTTTTTTTTCTAAATG TTCCTTCGCTTTCTTTCTTTCCTTTTTTT---TTTTTTTTTTTCTAAATG * * * ** ** * * * * * GAGACTCCCTCTCAGAAAAAAA-----------AAAGAAGGCCCAGTTAA GAGTTTTG------GAAAAAAA-----------AAAGAAGGCCCAGTTAA GAGTTTTG------CTCTGTTGTGCAGTGGTGCAGTCACAGCTCACTGCA *** * * * ** ** * * ATTTGAATTTCAGATAAACAATGAATAATTTTTT--CATATAATTATGTC ATTTGAATTTCAGATAAACAATGAATAATTTTTT--CATATAATTATGTC ATCTCAAACTCCTGGGCTCAAGCAACCCTCCCACCTCAGCTTCTCAAAGG ** * ** * * *** ** * ** * * * CTATGTGACATTTGGAATATATTTATACTAAAATTATGCATGCTTTATCT CTATGTGACATTTGGAATATATTTATACTAAAATTATGCATGCTTTATCT AGCTGAGACTATAGGCGTCTAT---------CACCATGCCTGG------- ** *** ** * *** * **** ** GAAATTAATTTTTTATTTTAATTTTTAT GAAATTAATTTTTTATTTTAATTTTTAT ---CTAGATTCTGCATTGCCA------- * *** * *** * CCAAAAAATAAAAAATAAAAATAAAAATAAAAGAAAATTCCTCACAAACGA CTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCT J-K J-[M] [M-N] CTGCCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCT ------CACTGCACTCCAGTC-TGGGAAACAGAGCAAGAC----TCTGTCT * ** ** *** ***** *** ** * ** GGCAAGAGTAAATATTTTTAAATGAGACATTAAGACCTGGGTTTTGGCTGC GGCAAGAGTAAATATTTTTAAATGAGACATTAAGACCTGGGTTTTGGCTGC ** * **** * * ** * * * * * * * * GTACAGTGGCTCACGCCTGTCATCTC--------AGCTCTTTGGGAAGTC A GTACAGTGGCTCACGCCTGTCATCTC--------AGCTCTTTGGGAAGTC A CTTCTGTAATCACCCCCTCTCCTGATTCATTATTTTTTCTTTAAAAACGT A * * ** * *** ** * ***** ** * AG -- TCAG ------------------------------------------- AG -- TCAG CCAGGCTCAGTGGCTTACTCCTGTAATCCCAGCACTTTGGGAG AG CC TCAG CCAGGCTCAGTGGCTTACTCCTGTAATCCCAGCACTTTGGGAG ** **** ----------GAGGATCATCAGCAGTCAGGTGTTTGAGACCAGCCTGGCCA ACTGAGGCGGGCGGATCAACTGAGGTTGGGAGTTCGAGACCACCTTGACCA ACTGAGGCGGGCGGATCAACTGAGGTTGGGAGTTCGAGACCACCTTGACCA ****** * * ** ** *** ******* * ** *** ACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAAGCATAT ****** ****** ********************* * * * ACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGTGTGGT ACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGTGTGGT TGGGTACCTGTAATCCCAGCTACTCGGGAGGGTGAGGCAGGAGAATTGCTT * GGCACA--------------------------------------------- GGCACA--------------------------------------------- WT PRR11 SMG8 GDPD1 YPEL2 LINC01476 I J K M N L PRR11 SMG8 GDPD1 YPEL2 LINC01476 SA-SV3 I J K L PRR11 SMG8 GDPD1 J M LINC01476 LINC01476 M N L I-J L-J L-M I-J L-J L-M I-J L-J L-M I-J L-J L-M I-J L-J L-M I-J L-J L-M J-K J-[M] [M-N] J-K J-[M] [M-N] J-K J-[M] [M-N] J-K J-[M] [M-N] J-K J-[M] [M-N] J-K J-[M] [M-N] -----TGGCAATGCAGAATCTAGCCAGGC-----ATGGTGATAGACGCCTATAGTCTCAGCTCCTTTGAGAAGCTGAGGTGGGAGGGTTGCTTGAGCCCAGGAGTTTGAGAT -----TGGCAATGCAGAATCTAGCCAGGCATGGTG-----ATAGACGCCTATAGTCTCAGCTCCTTTGAGAAGCTGAGGTGGGAGGGTTGCTTGAGCCCAGGAGTTTGAGAT CTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCATGACCCA---CCACGCCCAGCCTATGAACTATGAGACTTCTGA-------GAACTGTTAACA * *** * *** * ** * * * * * * ** *** * *** ** * * * * * [L-M] [M]-L K-L TGCAGTGAGCTGTGACTGCACCACTGCACTCCAGCCTGGGCAACAGAG C AAAACTCCATTTAGAAAAAAAAAAAAAAAAAAGGAAAGAA------AGAAAGCGAAGGAAGGAA TGCAGTGAGCTGTGACTGCACCACTGCACTCCAGCCTGGGCAACAGAG C CTGTCACGGTCCAGATTGTGCCACTCTTTGGAATTTCTGAATGGTATGAATCCAGAGGAGAGAA GGGAGGATAAATGGAGCCAGGAGACGCCTCACTTTGGCTTCAGTGGAA C CTGTCACGGTCCAGATTGTGCCACTCTTTGGAATTTCTGAATGGTATGAATCCAGAGGAGAGAA * ** ** ** * ** ** * * * * *** * * * *** * **** *** GGAAAGAAAAGGAAGAAAGAAAGAGAGAGAAGAAACAAAGACAAAGAAATGCAGGATCTCAGGCCCAACCCATTCCTACTAAATCAGCTCTG ACAACGTTCTGTTTGTTCTCATG-GGCCCTCATACCACAGACGTTTACATCATGGGCCTGC----ACACTGAGAGGTGCTGGTCATGTTTT- ACAACGTTCTGTTTGTTCTCATG-GGCCCTCATACCACAGACGTTTACATCATGGGCCTGC----ACACTGAGAGGTGCTGGTCATGTTTT- ** * * * * * * * ** **** * ** ** ** ** * * ** * * * [L-M] [M]-L K-L [L-M] [M]-L K-L MIR4729 MIR4729 Figure continues on next page