Maayke Hunfeld

129 Cause of death Non-survivors n = 62 number included patients p-value WLST- Neuro n =42 number included patients BD N=18 number included patients p-value 55 (89) 14 (23) 7 (12.7) 41 (67) 5 (14) 15 (24) 3 (2-4) 13 (87) 11 (73) 34 (55) 0.00 (0.00-0.75) 23 (70) 11 (18) 6 (55) 2 (29) 3 (75) (n=37) (n=15) (n=15) (n=15) (n=34) (n=34) (n=11) (n=11) (n=4) 0.018 0.475 0.752 0.125 0.396 <0.001 0.033 0.001 <0.001 0.130 0.5984 <0.001 0.614 0.151 0.497 0.207 37 (88) 13 (31) 7 (17) 25 (60) 5 (24) 11 (26) 3 (2-4) 11 (100) 7 (64) 26 (62) 0 (0 - 0) 18 (70) 6 (14) 4 (67) 1 (17) 1 (100) (n=21) (n=11) (n=11) (n=11) (n=26) (n=26) (n=6) (n=6) (n=1) 16 (89) 0 (0) 0 (0) 15 (83) 0 (0) 4 (22) 3 (2.5-4) 2 (50) 4 (100) 7 (39) 0 (0 - 0) 5 (71) 5 (28) 2 (40) 1 (20) 2 (67) (n=15) (n=4) (n=4) (n=4) (n=7) (n=7) (n=5) (n=5) (n=3) 1.000 0.006 0.091 0.084 0.062 1.000 0.903 0.057 0.516 0.156 0.216 1.000 0.279 0.567 1.000 0.104 medical condition contributed to the early WLST decision-making (two had severe pre-existent encephalopathy, one a brain tumor with no curative options and one a severe skeletal dysplasia with pulmonary hypoplasia). In eight children (36%), the presence of other severe injuries or organ failure was an important factor leading to early WLST decision-making (four had circulatory failure, two severe cervical spine and spinal cord injury, one severe traumatic brain injury, and one meningitis). Supplemental table 2 (Supplemental Digital Content 3, http://links.lww.com/ PCC/B540) summarizes the timing and rationale of WLST decision-making for each individual patient. Seventeen of the 22 patients (78%) had targeted TTM around the decision of WLST: (induced hypothermia n=15, with temperatures between 33-34° C, controlled normothermia n=2, with temperatures > 34 °C). At the time of decision-making, 40% of these patients were either receiving a sedative or opioid infusion during the neurologic examination, or the infusion was discontinued within 24 hours prior to the neurologic examination. Forty-eight percent of the total WLST-Neuro group (20/42), were monitored with regular or continuous EEG within 24 hours after CPR; isoelectric EEG 40%, low voltage 4