Maayke Hunfeld

157 MRI and prognosis Sensitivity (%) Specificity (%) PPV (%) NPV (%) MRI with or without injury and outcome Injury and outcome at discharge 20/22 (91%) 13/18 (72%) 20/25 (80%) 13/15 (87%) Injury and outcome only survivors at discharge * 7/9 (78%) 13/18 (72%) 7/12 (58%) 13/15 (87%) Injury and outcome at two years 16/16 (100%) 13/18 (72%) 16/21 (76%) 13/13 (100%) Injury and outcome only survivors at two years * 3/3 (100%) 13/18 (72%) 3/8 (38%) 13/13 (100%) MRI with or without focal injury and outcome Focal injury and outcome at discharge 6/22 (27%) 13/18 (72%) 6/11 (55%) 13/19 (68%) Focal injury and outcome at two years 4/16 (25%) 13/18 (72%) 4/9 (44%) 13/25 (52%) Focal injury with DGM and outcome at discharge 4/22 (18%) 14/18 (78%) 4/8 (50%) 14/32 (44%) Focal injury with DGM and outcome at two years 3/13 (23%) 14/18 (78%) 3/7 (43%) 14/27 (52%) Focal injury without DGM and outcome at discharge 2/22 (9%) 17/18 (94%) 2/3 (67%) 17/37 (46%) MRI with or without extensive injury and outcome Extensive injury and outcome at discharge 14/22 (63%) 18/18 (100%) 14/14 (100%) 18/26 (69%) Extensive injury and outcome only survivors at discharge * 3/9 (33%) 18/18 (100%) 3/3 (100%) 18/24 (75%) Extensive injury and outcome at two years 12/16 (75%) 18/18 (100%) 12/12 (100%) 18/22 (82%) Extensive injury and outcome only survivors at two years * 1/3 (33%) 18/18 (100%) 1/1 (100%) 18/20 (90%) Extensive injury with DGM and outcome at discharge 13/22 (60%) 18/18 (100%) 13/13 (100%) 18/27 (67%) Extensive injury with DGM and outcome at two years 11/16 (69%) 18/18 (100%) 11/11 (100%) 18/23 (78%) Table 3. Sensitivity, specificity, positive predictive value and negative predictive value for MRI findings and outcome * Including only patients who survived until hospital discharge ** Due to small sample size we did not include sensitivity, specificity, PPV and NPV for focal injury without DGM involvement and outcome at two years DGM=involvement of deep grey matter.NPV=negative predictive value; probability that children with normal MRI have a good neurological outcome PPV=positive predictive value; probability that children with MRI with injury have a poor outcome (poor neurological outcome or death) 5