Maayke Hunfeld

198 Chapter 6 Supplementary Table 3. Univariable andmultivariable logistic regression analyses of favorable neurologic outcome among hospital-survivors and total survival. Favorable neurologic outcome (PCPC 1-2 or ∆ PCPC 0) Total survival g (n = 360) among discharged patients at the longest follow-up interval f (n = 142) Crude Adjusted a1.b,c,d Crude Adjusted a2,b,c,d Variable OR [95%CI] p-Value OR [95%CI] p-Value OR [95%CI] p-Value OR [95%CI] p-Value Primary outcome measure Initial non-shockable rhythm aa,a2 referent referent referent referent Initial shockable rhythm a1,a2 5.5 [1.5 - 20.1] 0.011 1.8 [0.2 - 15.2] 0.589 7.4 [3.8 - 14.5] <0.001 9.6 [3.5 - 26.2] <0.001 Initial unkown rhythm a1,a2 8.7 [2.7 - 14.0] <0.001 8.8 [1.6 - 48.3] 0.011 25.6 [12.1 - 54.1] <0.001 5.1 [1.9 - 13.6] 0.001 Secondary outcome measure AED use b 0.7 [0.2 - 2.9] 0.652 0.1 [0.0 - 1.3] 0.087 1.2 [0.5 - 2.5] 0.672 0.3 [0.1 - 1.0] 0.051 Bystander BLS c 2.4 [0.9 - 6.7] 0.092 1.6 [0.4 - 6.7] 0.521 3.9 [2.3 - 6.7] <0.001 1.6 [0.7 - 3.5] 0.221 Year of event d 1.1 [1.0 - 1.2] 0.018 1.2 [1.1 - 1.3] 0.003 1.1 [1.0 - 1.1] <0.001 1.1 [1.1 - 1.2] <0.001 Post AED guideline change e 3.5 [1.5 - 8.5] 0.005 4.5 [1.5 - 13.5] 0.007 2.3 [1.5 - 3.7] <0.001 1.8 [0.9 - 3.4] 0.068 Abbreviations: AED = Automatic external defibrillator, BLS = Basic life support, CPR = Cardiopulmonary resuscitation, PCPC = Pediatric Cerebral Performance Category, ROSC = Return of spontaneous circulation. a1 Adjusted for follow-up duration, witnessed arrest, bystander CPR, age at arrest, year of event, first lactate, pre-existing conditions related to event and CPR duration. a2 Adjusted for witnessed arrest, bystander CPR, age at arrest, year of event, first lactate, pre-existing conditions related to event and CPR duration. b Adjusted for initial rhythm (shockable/non-shockable/unknown), bystander CPR, age at arrest, year of event, first lactate, socio-economic status and CPR duration. c Adjusted for initial rhythm (shockable/non-shockable/unknown), year of event, first lactate, socio-economic status and CPR duration. d Adjusted for initial rhythm (shockable/non-shockable/unknown). e Adjusted for initial rhythm (shockable/non-shockable/unknown), bystander CPR, age at arrest, socio-economic status and CPR duration. f Favorable neurologic survival defined as a post-arrest PCPC of 1-2 or a ∆ PCPC of 0. g Total survival amongst the included study population.