Maayke Hunfeld

44 Chapter 2 Supplemental table 2-8: Study description and results 2. NEUROLOGICAL EXAMINATION Source/Year Inclusion period Study type Number of centers N Age Hypothermia Outcome score Follow up interval Mandel 2002 (13) 1993-1996 Prospective Observational 1 N=57 with HIE (N=44 CA 77%) Total cohort: Median 28 mo (2 mo-15yrs) No PCPC and POPC score 24 hours and in third year after event in group with uncertain prognosis 1-2-3 defined as good outcome Carter 2005 (14) Inclusion period not specified Prospective Observational 1 N=102 with acute brain injury and coma (N=36 with HIE) Total cohort: Median age 4.46 yrs (0.08- 14.67yrs) Unknown GOS 5 years after event 4-5 defined as good outcome Abend 2012 (15) 2007-2009 Prospective Observational 1 N=35 Median age 1.02 yrs (0.18- 16.6yrs) Yes PCPC discharge PICU 4-6 defined as poor outcome (death defined as secondary outcome)