Maayke Hunfeld

60 Chapter 2 5. MRI BRAIN (continued) Source/ Year Inclusion period Study type Number of centers N Age group Hypo- thermia TimingMRI MRI sequences Outcome score Follow up interval Oualha 2013 (33) 2003-2010 Retro- spective 1 N=20 Median 20 mo (1.5-185mo) N=3 received hypo- thermia MRI performed mean 3 days (1-7) after CA DWI/ADC PCPC score (1-2-3 = good outcome) Up to 24 months Manchester 2016 (30) 2011-2013 Obser- vational, exploratory 1 N=14 Mean 5.8 yrs (± 6.5) Prevention of fever MRI performed mean 6 (±4) days after CA ADC and ASL PCPC score (1-2-3 = good outcome) Hospital discharge Yacoub 2018 (34) 2014- 2017 Retro- spective 1 N=26 Median 8.5 yrs (IQR 2.2- 14yrs) Normo- thermia MRI performed within 14 days after CA, median 4 days after CA ( IQR 2-7) Quantitative ADC in survivors remaining neurologically impaired after CA PCPC score (-1-2 = good outcome OR -no worsening from baseline score if baseline was ≥ 3 = good outcome) 6 months ADC=apparent diffusion coefficient, ASL=arterial spin labeling, CA=cardiac arrest, CBF=cerebral blood flow, DWI=diffusion weighted imaging, MRI=magnetic resonance imaging, ADC=apparent diffusion coefficient, ASL=arterial spin labeling, CBF=cerebral blood flow.