Maayke Hunfeld

64 Chapter 2 7. EVOKED POTENTIALS Source/ Year Inclusion period Study type Number of centers N Age group Hypo- thermia Timing EP Carter 1999 (38) 1991- 1993 Prospective Observational 1 N=105 with severe brain injury (n=38HIE) Median 4.4 yrs (0.1- 14.7yrs) unspecified SEP classification 1= bilateral normal 2= unilateral delayed N20 3= bilateral delayed N20 4= Unilateral absent N20 5= Bilateral absent N20 SEP < 7 days after event, median 16.8 h (1-163.5 h) Mandel 2002 (13) 1993- 1996 Prospective Observational 1 N=57 pts HIE (N=44 CA 77%) Total cohort: Median 28 mo (2mo- 15yrs) No SEP classification 1 = normal 2 =unilateral increased interpeak N13-N20 3=bilateral increased interpeak N13-N20 4= unilateral absence 5=bilateral absence Mean 2 days after admission (1-5 days) and in 10 pts second SEP mean 4 days after admission (2-11 days) BAEP Timing unclear Together with EEG (See EEG table) BAEP=brainstem auditorial evoked potential, CPR=cardiopulmonary resuscitation, EEG=electroencephalography, HIE=hypoxic-ischemic encephalopathy, HUI:1=Health Utilities Index Mark 1, HSUV=overall health state utility value, SEP=somatosensory evoked potentials.