Maayke Hunfeld

66 Chapter 2 8. BIOMARKERS Source/ Year Inclusion period Study types Number of centers N Age group Hypo- thermia Type of Biomarkers (plasma, CSF, other) Timing biomarkers Topjian 2009 (41) 2002-2004 Prospective, Observational 1 N=35 Median 4 yrs (IQR 0.8 –10yrs) Variable (5 received ht 32-34 ᵒ C) -Plasma NSE and S100b 4, 12, 24, 48, 72 and 96 hrs -Plasma PAI-1 24 hrs Fink 2014 (40) 2009-2011 Prospective Observational 1 N=43 Mean 5.87 yrs (IQR 0.33- 11.52yrs) Variable (81% received ht 33 ᵒ C) Plasma NSE, S100b and MBP twice day 1-4 and once day 7