Maayke Hunfeld

68 Chapter 2 8. BIOMARKERS (continued) Source/ Year Inclusion period Study types Number of centers N Age group Hypo- thermia Type of Biomarkers (plasma, CSF, other) Timing biomarkers Fink 2018 (42) 2009-2013 Pilot randomized controlled trial 1 N=34 Median 1.5 yrs (IQR (0.3- 9.8yrs) 50% 24 hrs ht 32-34 ᵒ C 50% 72 hrs ht 32-34 ᵒ C Plasma NSE, S100b and MBP twice day 1-4 and once day 7 Kramer 2018 (39) 2010-2016 Retrospective 1 N=95 Median 0.51 yrs (IQR 0.0- 17.1yrs) Variable, 68% targeted temperature (34-35 ᵒ C) Plasma NSE and S100b 12hrs, 24 hrs, 48 hrs and 72 hrs CA=cardiac arrest, HT=hypothermia, MBP=myelin basic protein, NSE=neuron-Specific Enolase, PAL1=plasminogen activator inhibitor-1, ROSC=return of spontaneous circulation, S100B=S100 Calcium-Binding-Protein B.