Maayke Hunfeld

69 Review neuromonitoring Outcome score Follow up interval Results Morta- lity (%) Limitations Grade Primary: biomarker concentrations day 7 (post- ROSC/post- rewarming) by HT group Secondary: PCPC (1-2-3 = good outcome, increase >1 poor outcome) Hospital discharge and 6 months Primary: NSE sign increased in 24 hrs ht group vs 72 hrs HT group at 84-96 hrs and day 7 S100B sign increased in 24 hrs ht group vs 72 hrs HT group at 12- 24hrs, 36-84 hrs and day 7 MBP sing increased in 24 hrs ht group vs 72 hrs HT group at 36-48 hrs Secondary: No outcome difference between 24 hrs ht group and 72 hrs HT group 35% -Small sample - PCPC non blinded and often by telephone interview -Crude outcome scale -time to randomization was up to 24 hrs 2B Primary: PCPC score (Good outcome= change of PCPC ≤ 1) Hospital discharge Secondary: in-hospital mortality Primary: -NSE peaked 24 hrs and remained elevated until 72 hrs in pts with poor outcome -NSE sign higher in pts with poor outcome at 24 hrs, 48 hrs and 72 hrs -S100b peaked at 12 hrs with decline afterwards in pts with poor outcome -S100b sign higher in pts with poor outcome immediately, at 12 hrs, 24hrs and 48 hrs -NSE and S100b peaked later in poor group compared to good outcome group Secondary: N=37 died 38% -Retrospective -13% abnormal baseline neurological status -Physician not blinded for biomarker results -neonates included -Narrow spectrum of arrest etiologies -Missing biomarker analysis -Short and crude outcome scale 2B/C 2