Joris van Dongen

118 Chapter 5 Moreover, chondrocytes are the cells that produce cartilage tissue and the co-culture of chondrocytes with tSVF-derived cells resulted in proliferation of chondrocytes and increased GAG deposition. The results of this study show that mechanically derived tSVF is able to promote chondrocyte proliferation and suppress chondrocyte inflammation in vitro . As a result, tSVF has shown to have an anti-inflammatory as well as a pro-regenerative effect on chondrocytes. Consequently, tSVF as a treatment for osteoarthritis seems to be very promising. To further elucidate the beneficial effect of tSVF on osteoarthritis clinically, prospective randomized clinical trials are necessary.