Joris van Dongen

153 The power of fat and ASCs for scar treatment: a review Follow up Results Complications Photographic analysis by 3 independent observers using a visual 5-grade scale (mean follow- up of 24.7 months). Less cleft lip related deformity in overall facial, upper lip, nose and midface appearance in treated group.* No complications reported Visual evaluation of the lower extremity. Patient noted improvement in mobility and appearance, less neuralgic pain, No complications reported Visual evaluation of photographs (pre-operative, 1 month and 3 months postoperative). Among 28 interventions, 24 showed visual improvement in skin quality. 1 case showed improvement initially, but not after 3 months. No complications reported Immunohistochemical analysis of scar biopsies, subjective evaluation using a questionnaire, photographic analysis by independent observers using the VSS (preoperative, 3 months and 6 months postoperative). After 6 months, a decrease in Langerhans cells and increase in P53 and Ki67.** No difference in P67 count. Improvements in VSS scores from 41 (preoperative) to 15 (6 months postoperative) and questionnaire scores from 31 (pre- operative) to 95 (6 months postoperative) compared to untreated group. Not mentioned Aesthetic, functional and satisfaction scores were measured using a TAM (Goniometer), GSM (Dynamometer), DASH, MHQ and POSAS after 9.1 months [range 3 months – 1.3 years] The mobility improved*, but there was no grip strength and DASH improvement. A trend towards significant improvement in MHQ scores was noticed. A significant improvement in the POSAS scores was visible, except the scores for pain and itch. No complications reported Visual evaluation of photographs (pre-operative, 11 months and 3 years and 7 months postoperative). Visual improvement in skin quality. Not mentioned Photographic analysis by 2 independent observers using a visual 4-grade scale (mean follow- up of 18 months). Improvement in skin quality, 5 cases obtained a score of 4 and 3 cases obtained a score of 3. No complications reported Histological evaluation of scar biopsies and MRS (preoperative, 13 months postoperative during operation 2, 3 months postoperative). Histological improvement: patterns of new collagen deposition and more dermal hyperplasia and neoangiogenesis. Presence of annexial structures is nearly normal. MRS revealed similar signal enhancement of sof tissue between affected and unaffected facial sides. Not mentioned Amodified POSAS and durometer measurements to measure skin hardness were performed (preoperative and 3 months postoperative). Reduction of scar hardness after treatment*, while no significant reduction occurred in the control group. Reduction of all POSAS parameters, except itching in the treatment group.* No POSAS scores in control group reported. Not mentioned