Joris van Dongen

158 Chapter 7 Table 1b. Clinical studies on lipofilling to reduce pain. Reference Study type Study population Intervention Caviggioli et al. 2011 Retrospective, controlled Patients with severe scar retraction and PMPS after mastectomy with axillary dissection and radiotherapy (n=113). Intervention: dermal-hypodermal junction lipofilling (n=72) Control: no lipofilling treatment (n=41). Huang et al. 2015 Prospective, non-controlled, non-blinded, non- randomized Patients with painful neuropathic scars with persistent symptoms (n=13). [range 3 months - 13 months] Intervention: dermal-hypodermal junction and subcutaneous lipofilling. Klinger et al. 2013 Retrospective, semi-controlled non-blinded, non- randomized Patients with retractile and painful scars compromising daily activity (n=20). Scar age of > 2 years. Intervention: dermo-hypodermic junction lipofilling. Control: saline injection. Maione et al. 2014 Prospective, controlled, non-blinded, non- randomized Patients with PMPS after lumpectomy and radiotherapy (n=96). Lipofilling performed >1 year after radiotherapy. Intervention: dermal-hypodermal junction lipofilling (n=59). Control: no lipofilling treatment (n=37). Panettiere et al. 2009 Prospective, controlled, non-blinded, non- randomized Patients with irradiated reconstructed breasts after mastectomy for carcinomas (n=61, 62 breasts). Intervention: subscar lipofilling (serial interventions till patient was satisfied or result was stable). (n=20) Control: no lipofilling treatment (n=41). Rigotti et al. 2007 Prospective, non-controlled, non-blinded, non- randomized Patients with side effects of radiotherapy with severe symptoms and irreversible function damage (LENT- SOMA scale grade 3 and 4)(n=20). Scar age 1 -30 years. Intervention: purified lipofilling. Ulrich et al. 2012 Prospective, non-controlled, non-blinded, non- randomized Patients with painful episiotomy scars (n=20). Mean time after episiotomy was 10.3 months. Intervention: subscar lipofilling Abbreviations: VSS = Vancouver Scar Scale, TAM = Total Active Movement, GSM = Grip Strength Measurement, DASH = The Disabilities of the Arm, Shoulder and Hand, MHQ = Michigan Hand outcome Questionnaire, POSAS = Patient and Observer Scar Assessment Scale, MRS = Magnetic Resonance Scan, MRM = Modified Radical Mastectomy, IIBR = Immediate Implant-Based Reconstruction, PMRT = Post-