Joris van Dongen

248 Chapter 11 ABSTRACT Introduction Autologous lipografting for improvement of facial skin quality was first described by Coleman in 2006. The current dogma dictates that adipose tissue-derived stromal cells (ASCs) which reside in the stromal vascular fraction (SVF) of lipograft contribute to skin rejuvenation e.g. increased skin elasticity, a more homogenous skin color and softening of skin texture. Nowadays, many studies have been reported on this ‘skin rejuvenation’ effect of autologous fat grafting. This systematic review was undertaken to assess the efficacy of autologous lipografting on skin quality. Material & Methods MEDLINE, Embase, Cochrane Central, Web of Science and Google Scholar databases were searched for studies evaluating the effect of autologous lipografting on facial skin quality (05-11-2018). Outcomes of interest were skin texture, color and elasticity as well as histological outcomes and number of complications. Resul ts Nine studies were included with 301 patients treated in total. No meta-analysis could be performed due to heterogeneity of the metrics and outcomes. Eight studies reported increased skin elasticity, improvement in skin texture as well as a more homogeneous skin color after treatment with lipografting, cellular SVF or Nanofat. One study reported no increased skin elasticity after lipografting. Histological improvement was seen after lipografting and ASCs injections. However, in general, the level of evidence of the included studies was low. No serious complications were reported. Conclusion Autologous facial lipografting as well as cSVF and ASCs injections hardly seem to improve facial skin quality but can be considered as a safe procedure.