Joris van Dongen

253 Facial lipografting on skin quality: a systematic review Table 2. Quality assessment of included studies according to the OCEBM criteria. Author, year Level of evidence Amirkhani et al. 2016 4 Botti et al. 2011 3 Charles-de-Sá et al. 2015 4 Covarrubias et al. 2013 2 Liang et al. 2018 3 Rigotti et al. 2016 4 Song et al. 2017 4 Trivisonno et al. 2017 4 Willemsen et al. 2017 2 OCEBM = Oxford Center for Evidence-Based Medicine Study characteristics Eight of the nine included studies were prospective clinical trials 19,21,22,96-100 , six of these eight were controlled studies and of the latter mentioned six studies 19,21,22,96,98,100 , two had been randomized. 21,100 In total, 301 subjects were treated. All studies included a 93% female study population. All studies reported the range of age while four studies reported the mean age too. 19,22,96,100 Willemsen et al. reported an overall Body Mass Index between 20-25, which was already stable for one year (Table 3). 100 Adipose tissue harvesting and processing All studies reported which donor site had been used. Eight studies used infiltration prior to liposuction 19,21-23,96,97,99,100 and one study by Charles-de-Sá et al. did not mention any infiltration step (Table 4). 20 Five out of the seven studies that used lipografting used decantation to process the adipose tissue prior to injection. 20-24 Two studies processed the adipose tissue by centrifugation of which one used the standard Coleman technique. 19,25 Three studies used enzymatic isolation to isolate SVF (cSVF). 18,20,22 One study used the so-called Nanofat which essentially is an emulsification procedure of lipoaspirates (Table 4). 96