Joris van Dongen

254 Chapter 11 Table 3. Study characteristics and patient demographics. Author, year Study Type Sex Mean age (y) + sd Range (y) BMI Male Female Amirkhani et al. 2016 Prospective, non-blinded, non-randomized, non- controlled clinical trial 1 15 - 38-56 - Botti et al. 2011 Prospective, double-blinded, non-randomized, controlled clinical trial 4 21 46.3 21-72 - Charles-de-Sá et al. 2015 Prospective, non-blinded, non-randomized, controlled clinical trial 1 5 - 45-65 - Covarrubias et al. 2013 Prospective, single-blinded, randomized, controlled clinical trial 16 - 40-70 - Liang et al. 2018* Prospective, non-blinded, non-randomized, controlled clinical trial 12 91 28.5 24-55 - Rigotti et al. 2016 Prospective, non-blinded, non-randomized, controlled clinical trial 2 11 56.2 45-65 - Song et al. 2017 Retrospective, non-blinded, non-randomized, case- control study 76 - 26-53 - Trivisonno et al. 2017 Prospective, non-blinded, non-randomized, non- controlled clinical trial 2 19 - 35-62 - Willemsen et al. 2017 Prospective, double-blind, randomized, placebo- controlled clinical trial 25 52 ± 6.75 38-63 20-25 (1 year stable) * Sex, mean age + sd and range are only given for the experimental group. No demographic data of the control group (n=128) could be extracted.