Birgitta Versluijs

171 Discussion FIGURE 1. Proposed pathophysiologic mechanism involved in Allo-LS. FIGURE 2. Currently used or studied treatment options for Allo-LS, in relation to proposed pathophysiologic mechanism. conditioning regimen infection iron overload transfusions endothelial injury epithelial injury oxidative stress Innate immunity neutrophils macrophages Donor T cells TH-2, TH,17 Tregs Gut GvHD Fibroblasts B cells Collagen LPS TNF-alpha IL-17 IL-8 IL-6 MHC expression PDGF-R TGF-beta Antibodies Azithromicin Etanercept sdior etS Montelukast Rituximab Calcineurin inhibitors Sirolimus PCE Pirfenidone Bortezomib 9 conditioning regimen infection iron overload transfusions endothelial injury epithelial injury oxidative stress Innate immunity neutrophils macrophages Donor T cells TH-2, TH,17 Tregs Gut GvHD Fibroblasts B cells Collagen LPS TNF-alpha IL-17 IL-8 IL-6 MHC expression PDGF-R TGF-beta Antibodies