Birgitta Versluijs

All rights reserved. No part of this thesis may be reproduced or transmitted in any form by any means without permission in writing of the author. The copyright of the articles that have been published has been transferred to the respective journals. Publication of this thesis was kindly supported by the University Medical Center Utrecht. Copyright © 2018, Birgitta Versluijs, Utrecht, The Netherlands. Author Birgitta Versluys Cover design Birgitta Versluys Layout by Menno van den Bergh Printing Ridderprint BV |  www.ridderprint.nl ISBN 978-94-6299-916-9