Birgitta Versluijs

53 Association between respiratory virus and alloimmune lung syndromes FIGURE 1. RV= Respiratory Virus, allo-LS = alloimmune lungsyndrome, aGVHD = acute graft versus host disease, IPS = Idiopathic Pulmonary Syndrome, BO = Bronchiolitis Obliterans (Syndrome). 3 Occurence of allo-LS according to respiratory virus positivity in NPA Occurence of allo-LS according to aGvHD (> grade 1) Time to allo-LS (weeks) Time to allo-LS (weeks) Cum allo-LS Cum allo-LS Cum allo-LS Cum survival Time to allo-LS (weeks) Follow-up post-SCT (weeks) 1,0 0,8 0,6 0,4 0,2 0,0 1,0 0,8 0,6 0,4 0,2 0,0 1,0 0,8 0,6 0,4 0,2 0,0 1,0 0,8 0,6 0,4 0,2 0,0 Log rank = 0.000 RV positivity Negative Positive Negative-censored Positive-censored aGvHD No Yes ,00-censored 1,00-censored Occurence of allo-LS in RV-positive patients according to aGvHD (>1) Overall survival according to Allo-LS aGvHD No Yes ,00-censored 1,00-censored No Yes no-censored yes-censored Allo-LS (IPS + BO) Log rank = 0.049 Log rank = 0.008 Log rank = 0.000 0,00 20,00 40,00 60,00 80,00 100,00 0,00 20,00 40,00 60,00 80,00 100,00 0,00 20,00 40,00 60,00 80,00 100,00 0 50 100 150 200 250 A B C D