Birgitta Versluijs

68 Results TABLE 1. Characteristics of 52 patients in study population. Characteristic No. Median age at transplantation (range) in years 4.4 (0.2-17.5) Male 29 (56) HCT indication  Malignant  Nonmalignant 21 (40) 31 (60) Donor type  Matched related  Matched unrelated  Mismatched unrelated 10 (19) 20 (38) 22 (42) Stem cell source  Bone marrow  Cord blood 22 (42) 30 (58) Conditioning regimen  Chemotherapy-based  Total body irridiation-based 47 (90) 5 (10) Note—Except where indicated otherwise, data in parentheses are percentages. a Malignant diseases included acute lymphoblastic leukemia (n = 9); acute myeloid leu- kemia, chronic myeloid leukemia, or myelodysplastic syndrome (n = 9); and lymphoma (n = 3). Nonmalignant disorders included bone marrow failure (n = 7), inherited immune deficiency (n = 13), and inborn errors of metabolism (n = 11). b Matched donor was defined as 10/10 for bone marrow/peripheral blood stem cell mole- cularly typed or 6/6 for cord blood on basis of intermediate resolution (human leukocyte antigen [HLA]-A and HLA-B on serology) and high-resolution (HLA-DR). c Standard chemotherapy-based conditioning consisted of busulfan (IV, targeted on AUC of 85–95 mg × h × L) in combination with cyclophosphamide (120 mg/kg) or fludarabine (160 mg/m 2 in 4 days). Total body irradiation was given as six fractions of 2 Gy in three consecutive days followed by etoposide (60 mg/kg). 4