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A putative anti-inflammatory role for TRPM8 in IBS 117 5 IBS-D IBS-C IBS-M IBS-U HC 0 5 10 15 TRPM8 +ve cells/field of view ** **** *** *** ** TRPM8 CD45 Merge NORMAL INFLAMED Supplementary Material Figure S5.1 Expression of TRPM8 on CD45+ cells in normal, uninflamed and inflamed (Crohn's disease) mucosa. Arror points to CD45+ cell that co-expresses TRPM8 Scale bar = 10 µm. Figure S5.2 TRPM8-immunoreactive (IR) cells/field of view classified by IBS sub-types. Data is presented as median and interquartile range ( N : IBS-D=6, IBS-C=4, IBS-Mixed=8, IBS (unclassified)=10 & Healthy controls=7).