Zsa Zsa Weerts

Chapter 6 138 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 1 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 3 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 5 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 7 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 2 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 4 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 1400 Time (min) Plasma menthol-glucuronide (µg/L) Subject 6 Small-intestinal release peppermint oil Ileocolonic release peppermint oil 0 60 120 180 240 300 360 420 480 540 600 660 720 780 840 1440 0 200 400 600 800 1000 1200 Time (min) Plasma menthol-glucuronide (µg/L) Subject 8 Small-intestinal release peppermint oil Ileocolonic release peppermint oil Supplementary Material Figure S6.1 Concentration-time curve, menthol-glucuronide concentration was measured in healthy volunteers ( N =8) in ug/mL on 14 time points after both peppermint oil (PO) capsule administrations.