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Chapter 7 152 N=64 N=62 N=63 0 20 40 60 80 100 Abdominal pain responders (%) 34.4% 46.8% 41.3% N=64 N=62 N=63 0 10 20 30 Global relief responders (%) 4.7% 9.7% 1.6% Ileocolonic release peppermint oil Placebo Small-intestinal release peppermint oil Figure 7.1 Percentage of patients who were abdominal pain responders (a) and global relief responders (b) in the ITT-population. (a) Abdominal pain responder: a patient with at least 30% decrease in mean worst daily abdominal pain in at least 4 out of 8 weeks. (b) Global relief responder: a patient with at least a relief score of 6 or 7 (on a 7-point NRS) in at least 4 out of 8 weeks. Values are percentages, bars represent standard errors. Secondary efficacy outcomes Results of exploratory secondary outcomes are presented in Table 7.2 and Supplementary Table S7.4 . The small-intestinal release peppermint oil resulted in significantly more reduction in daily worst abdominal pain at week eight, with a corrected difference in change from baseline on an 11-point NRS, compared with placebo, of -0.63 (95%CI, - 1.14, -0.12; P =0.016) ( Supplementary Table S7.4 ).