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Chapter 7 164 Supplementary Material Table of contents Detailed inclusion and exclusion criteria Treatment allocation Statistical analysis of secondary outcomes Supplementary Tables Table S7.1 Adherence to study medication and compliance to the digital symptom diary (ITT-population) Table S7.2 Number needed to treat and number needed to harm (ITT-population) Table S7.3 Responder endpoints (PP-population) Table S7.4 Other secondary efficacy endpoints (ITT-population) Table S7.5 Stool frequency and stool consistency (ITT-population) Table S7.6 Stool frequency and stool consistency in patients with IBS subtype diarrhea Table S7.7 Stool frequency and stool consistency in patients with IBS subtype constipation Table S7.8 Use of rescue medication (ITT-population) Supplementary Figures Figure S7.1 Study design of the PERSUADE study Figure S7.2 CONSORT flowchart of patient flow throughout the study Figure S7.3 Percentage of moderate relief responders Figure S7.4 Stool consistency Figure S7.5 Stool frequency Figure S7.6 Belching scores Exploratory Supplementary Analyses of primary endpoints Exploratory Supplementary Analyses of effect modification