Zsa Zsa Weerts

Efficacy and safety of peppermint oil in IBS 169 7 Table S7.4 (continued) Measurement Placebo N =64 Small-intestinal release Peppermint oil N =62 Ileocolonic release Peppermint oil N =63 Estimated means (SE) Estimated means (SE) Treatment effect (95% CI) P- value Estimated means (SE) Treatment effect (95% CI) P- value Abdominal bloating ± Baseline Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 6.53 (0.38) 5.51 (0.38) 5.06 (0.38) 5.21 (0.38) 5.03 (0.38) 4.74 (0.38) 5.04 (0.39) 4.96 (0.39) 4.52 (0.39) 6.44 (0.39) 5.15 (0.40) 4.97 (0.39) 4.63 (0.40) 4.19 (0.40) 4.22 (0.40) 4.10 (0.40) 3.81 (0.40) 4.03 (0.40) - -0.27 (-1.28; 0.73) -0.00 (-0.98; 0.97) -0.49 (-1.45; 0.47) -0.75 (-1.67; 0.17) -0.44 (-1.32; 0.44) -0.86 (-1.72; 0.00) -1.07 (-1.87; -0.26) -0.43 (-1.19; 0.33) - 0.594 0.994 0.316 0.109 0.328 0.051 0.009 0.269 6.68 (0.38) 5.52 (0.38) 5.45 (0.39) 5.11 (0.39) 4.58 (0.39) 4.77 (0.39) 4.51 (0.39) 4.06 (0.40) 4.18 (0.39) - -0.15 (-1.15; 0.86) 0.23 (-0.75; 1.21) -0.25 (-1.22; 0.72) -0.61 (-1.54; 0.33) -0.13 (-1.02; 0.77) -0.69 (-1.55; 0.17) -1.06 (-1.87; -0.24) -0.52 (-1.28; 0.24) - 0.772 0.646 0.607 0.203 0.778 0.114 0.011 0.180 Abdominal cramping ± Baseline Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 6.10 (0.33) 4.87 (0.35) 4.87 (0.37) 4.76 (0.39) 4.86 (0.37) 4.97 (0.38) 5.03 (0.39) 4.40 (0.39) 4.36 (0.42) 5.91 (0.34) 5.07 (0.36) 4.73 (0.39) 4.57 (0.40) 4.46 (0.38) 4.36 (0.39) 4.18 (0.40) 3.69 (0.40) 3.83 (0.43) - 0.38 (-0.38; 1.15) 0.04 (-0.85; 0.93) -0.01 (-0.96; 0.94) -0.21 (-1.10; 0.69) -0.42 (-1.29; 0.45) -0.66 (-1.54; 0.22) -0.52 (-1.36; 0.31) -0.34 (-1.17; 0.49) - 0.322 0.929 0.984 0.648 0.345 0.140 0.218 0.419 6.15 (0.33) 5.93 (0.35) 5.56 (0.38) 5.12 (0.40) 4.86 (0.39) 4.83 (0.39) 4.85 (0.39) 4.88 (0.40) 4.23 (0.42) - 1.01 (0.25; 1.77) 0.64 (-0.26; 1.54) 0.31 (-0.66; 1.27) -0.05 (-0.97; 0.86) -0.19 (-1.08; 0.69) -0.24 (-1.11; 0.64) 0.43 (-0.42; 1.27) -0.18 (-1.02; 0.66) - 0.010 0.163 0.533 0.910 0.668 0.597 0.323 0.673