Zsa Zsa Weerts

Chapter 7 170 Table S7.4 (continued) Measurement Placebo N =64 Small-intestinal release Peppermint oil' N =62 Ileocolonic release Peppermint oil N =63 Estimated means (SE) Estimated means (SE) Treatment effect (95% CI) P- value Estimated means (SE) Treatment effect (95% CI) P- value Belching ± Baseline Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 3.41 (0.35) 2.92 (0.35) 3.10 (0.34) 2.95 (0.38) 2.75 (0.37) 2.68 (0.36) 2.65 (0.38) 2.31 (0.34) 2.49 (0.36) 3.65 (0.36) 4.87 (0.36) 4.42 (0.34) 3.70 (0.35) 3.21 (0.33) 2.59 (0.29) 2.96 (0.36) 2.90 (0.38) 2.88 (0.34) - 1.85 (0.86; 2.83) 1.10 (0.15; 2.05) 0.52 (-0.42; 1.45) 0.24 ((-0.66; 1.13) -0.27 (-1.13; 0.59) 0.29 (-0.55; 1.14) 0.20 (-0.59; 0.99) 0.17 (-0.58; 0.92) - 0.0003 0.023 0.276 0.605 0.534 0.493 0.627 0.655 3.41 (0.36) 2.98 (0.35) 3.00 (0.36) 2.84 (0.40) 2.18 (0.30) 2.43 (0.38) 2.19 (0.33) 2.15 (0.36) 1.74 (0.28) - 0.25 (-0.73; 1.24) 0.06 (-0.90; 1.02) 0.03 (-0.92; 0.98) -0.31 (-1.22; 0.60) -0.18 (-1.05; 0.69) -0.33 (-1.17; 0.51) -0.13 (-0.93; 0.67) -0.53 (-1.28; 0.23) - 0.615 0.898 0.952 0.506 0.683 0.440 0.754 0.169 Nausea ± Baseline Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 2.89 (0.39) 3.82 (0.40) 2.70 (0.40) 2.86 (0.40) 2.76 (0.40) 2.63 (0.40) 2.33 (0.40) 2.33 (0.40) 2.20 (0.41) 3.29 (0.40) 2.71 (0.41) 2.58 (0.41) 2.15 (0.41) 2.07 (0.41) 2.12 (0.41) 2.06 (0.42) 2.02 (0.42) 1.92 (0.42) - -0.50 (-1.51; 0.50) -0.52 (-1.49; 0.46) -1.10 (-2.07; -0.13) -1.08 (-2.02; -1.44) -0.91 (-1.82; 0.00) -0.66 (-1.56; 0.24) -0.71 (-1.57; 0.15) -0.67 (-1.50; 0.16) - 0.327 0.300 0.026 0.024 0.051 0.151 0.108 0.115 3.56 (0.39) 3.08 (0.40) 2.87 (0.40) 2.69 (0.41) 2.00 (0.41) 2.21 (0.41) 2.64 (0.40) 2.15 (0.41) 1.81 (0.41) - -0.40 (-1.40; 0.61) -0.49 (-1.48; 0.50) -0.83 (-1.81; 0.15) -1.42 (-2.38; -0.46) -1.08 (-2.01; -0.16) -0.35 (-1.25; 0.55) -0.84 (-1.71; 0.04) -1.05 (-1.89; -0.21) - 0.437 0.329 0.097 0.004 0.051 0.447 0.060 0.015