Zsa Zsa Weerts

Efficacy and safety of peppermint oil in IBS 171 7 Table S7.4 (continued) Measurement Placebo N =64 Small-intestinal release Peppermint oil N =62 Ileocolonic release Peppermint oil N =63 Estimated means (SE) Estimated means (SE) Treatment effect (95% CI) P- value Estimated means (SE) Treatment effect (95% CI) P- value Urgency ± Baseline Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 6.41 (0.32) 5.56 (0.33) 5.34 (0.33) 5.56 (0.33) 5.42 (0.33) 5.12 (0.33) 4.90 (0.33) 5.09 (0.33) 5.06 (0.33) 6.55 (0.33) 5.74 (0.34) 5.73 (0.34) 5.25 (0.34) 5.15 (0.34) 5.06 (0.34) 4.68 (0.35) 4.61 (0.34) 4.57 (0.35) - 0.04 (-0.87; 0,96) 0.25 (-0.64; 1.14) -0.45 (-1.33; 0.43) -0.41 (-1.26; 0.43) -0.20 (-1.02; 0.62) -0.36 (-1.17; 0.45) -0.61 (-1.37; 0.15) -0.63 (-1.35; 0.10) - 0.926 0.577 0.316 0.342 0.634 0.386 0.116 0.091 6.73 (0.32) 5.88 (0.33) 5.93 (0.33) 5.70 (0.34) 5.36 (0.34) 5.41 (0.34) 5.24 (0.33) 5.22 (0.34) 4.97 (0.34) - 0.01 (-0.91; 0.92) 0.28 (-0.62; 1.18) -0.18 (-1.07; 0.71) -0.38 (-1.23; 0.49) -0.03 (-0.86; 0.81) 0.04 (-0.77; 0.84) -0.18 (-0,96; 0.59) -0.40 (-1.13; 0.33) - 0.988 0.541 0.695 0.395 0.949 0.930 0.645 0.282 IBS symptom severity † Baseline Week 2 Week 4 Week 6 Week 8 Month 6* 276.53 (11.68) 244.21 (14.10) 234.16 (13.77) 230.68 (14.42) 226.80 (14.97) 215.66 (13.97) 284.52 (12.10) 232.82 (14.50) 218.33 (14.21) 206.13 (14.90) 192.99 (15.45) 213.31 (14.42) - -19.38 (-48.01; 9.25) -23.81 (-54.61; 6.98) -32.52 (-66.07; 1.03) -41.79 (-76.88; -6.70) -8.86 (-42.03; 24.31) - 0.183 0.129 0.057 0.020 0.600 285.42 (11.65) 255.65 (14.15) 221.10 (13.94) 222.10 (14.58) 201.05 (15.14) 224.28 (14.11) - 2.56 (-26.06; 31.18) -21.95 (-52.85; 8.95) -17.45 (-15.01; 16.11) -34.64 (-69.75; 0.48) -0.02 (-33.27; 33.23) - 0.860 0.163 0.306 0.053 0.999 IBS quality of life score µ Baseline Week 4 Week 8 Month 6* 70.47 (2.47) 73.66 (2.47) 75.01 (2.50) 74.70 (2.52) 68.75 (2.56) 72.87 (2.56) 75.85 (2.59) 72.79 (2.61) - 0.93 (-1.75; 3.60) 2.56 (-0.17; 5.29) -0.31 (-3.34; 2.71) - 0.495 0.066 0.838 69.77 (2.47) 74.01 (2.47) 75.54 (2.50) 73.92 (2.52) - 1.05 (-1.65; 3.75) 1.24 (-1.50; 3.97) -0.13 (-3.17; 2.90) - 0.443 0.374 0.931 EQ-5D-5L ♮ Baseline Week 4 Week 8 Month 6* 0.70 (0.03) 0.71 (0.03) 0.72 (0.03 0.79 (0.03) 0.71 (0.03) 0.76 (0.03) 0.77 (0.03) 0.78 (0.03) - 0.04 (-0.01; 0.10) 0.04 (-0.01; 0.10) -0.02 (-0.75; 0.04) - 0.110 0.131 0.509 0.72 (0.03) 0.73 (0.03) 0.74 (0.03) 0.77 (0.03) - 0.00 (-0.05; 0.06) 0.00 (-0.05; 0.06) -0.04 (-0.09; 0.02) - 0.943 0.914 0.174