Zsa Zsa Weerts

Chapter 7 176 Table S7.8 Use of rescue medication (ITT-population). Placebo Small-intestinal release Peppermint oil Ileocolonic release Peppermint oil N =64 N =62 N =63 Pain medication Mean frequency of use (SE) ¶ Number of patients (%) ‡ 5.16 (0.82) 50 (78.1) 3.71 (0.59) 44 (71.0) 3.16 (0.48) 46 (73.0) GI-medication ± Mean frequency of use (SE) ¶ Number of patients (%) ‡ 5.05 (0.81) 53 (82.8) 4.42 (0.63) 48 (77.4) 3.17 (0.46) 45 (71.4) ¶ Mean frequency of use per patient during the eight-week treatment period; ± GI-medication comprises of i.e. antacids, laxatives, and anti-diarrheal drugs; ‡ Number of patients and percentage of patients that used the medication at least once during the eight-week treatment period. The differences in mean frequency between small- intestinal release peppermint oil and placebo ( P =0.087 for pain medication, P= 0.457 for GI-medication) and ileocolonic release peppermint oil and placebo ( P =0.039 for pain medication, P =0.044 for GI medication) did not reach statistical significance ( α =0.025).