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Efficacy and safety of peppermint oil in IBS 179 7 N=64 N=62 N=63 0 20 40 60 80 100 Moderate relief responders (%) 20.3% 38.7% 20.6% Ileocolonic release peppermint oil Placebo Small-intestinal release peppermint oil Figure S7.3 Percentage of patients who were moderate relief responders in the ITT-population. A responder was a patient with at least a relief score of 5, 6 or 7 (on a 7-point NRS) in at least 4 weeks out of 8 weeks. Values are percentages, bars represent standard errors. P =0.030 for small-intestinal release peppermint oil, P =0.980 for ileocolonic release peppermint oil, both compared with placebo.