Zsa Zsa Weerts

Chapter 7 180 0 1 2 3 4 5 6 7 8 1 2 3 4 5 6 Weeks Average stool consistency (BSFS) ITT-population 0 1 2 3 4 5 6 7 8 1 2 3 4 5 6 Weeks Average stool consistency (BSFS) IBS-D 0 1 2 3 4 5 6 7 8 1 2 3 4 5 6 Weeks Average stool consistency (BSFS) IBS-C Placebo Small-intestinal release peppermint oil Ileocolonic release peppermint oil A B C Figure S7.4 A . Stool consistency in the ITT-population ( N =189), B . Stool consistency in the IBS-C population ( N =42), C . Stool consistency in the IBS-D population ( N =83). Values are adjusted estimated marginal means derived from the linear mixed model, bars represent standard errors. The small-intestinal peppermint oil group had significantly more increase in stool consistency at week 6 compared to placebo ( P =0.018). Assessed daily using the Bristol stool form scale (BSFS) in the digital diary.