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Efficacy and safety of peppermint oil in IBS 181 7 0 1 2 3 4 5 6 7 8 0 4 8 12 Weeks Spontaneous Bowel Movements ITT-population 0 1 2 3 4 5 6 7 8 0 5 10 15 Weeks Spontaneous Bowel Movements IBS-D 0 1 2 3 4 5 6 7 8 0 5 10 15 Weeks Spontaneous Bowel Movements IBS-C A B C Placebo Ileocolonic release peppermint oil Small-intestinal release peppermint oil Figure S7.5 A . Stool frequency in the ITT-population ( N =189), B . Stool frequency in the IBS-C population ( N =42), C . Stool frequency in the IBS-D population ( N =83). Values are adjusted estimated marginal means derived from the linear mixed model, bars represent standard errors. Assessed daily in the digital diary.