Zsa Zsa Weerts

Chapter 9 234 �2 �1 0 1 2 3 4 5 6 7 8 3 6 Run�in�period weeks Treatment period At t = 0 weeks • Demographics • IBS�SSS • IBS�QoL • EQ�5D • PHQ�9 & GAD�7 14 days symptom diary 56 days symptom diary At t = 2 weeks • IBS�SSS At t = 4 weeks • IBS�SSS • IBS�QoL • EQ�5D At t = 8 weeks, 3 & 6 months • IBS�SSS • IBS�QoL • EQ�5D • PHQ�9 & GAD�7 t = 0 weeks Inclusion Randomization visit t = �2 weeks Screenings visit Informed Consent t = 2 weeks Telephone follow�up t = 4 weeks Telephone follow�up t = 6 weeks Telephone follow�up t = 8 weeks End of treatment visit At t = 6 weeks • IBS�SSS Follow�up period months Supplementary Figures