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General introduction 25 1 71. Elsenbruch S, Rosenberger C, Bingel U, et al. Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology 2010;139:1310-1319. 72. Lowen MB, Mayer E, Tillisch K, et al. Deficient habituation to repeated rectal distensions in irritable bowel syndrome patients with visceral hypersensitivity. Neurogastroenterol Motil 2015;27:646-655. 73. Wilder-Smith CH. The balancing act: endogenous modulation of pain in functional gastrointestinal disorders. Gut 2011;60:1589- 1599. 74. Rapps N, van Oudenhove L, Enck P, et al. Brain imaging of visceral functions in healthy volunteers and IBS patients. J Psychosom Res 2008;64:599-604. 75. Albusoda A, Ruffle JK, Friis KA, et al. Systematic review and meta-analysis: conditioned pain modulation in patients with the irritable bowel syndrome. Aliment Pharmacol Ther 2018;48(8):797-806 76. Simren M, Tornblom H, Palsson OS, et al. Management of the multiple symptoms of irritable bowel syndrome. Lancet Gastroenterol Hepatol 2017;2:112-122. 77. McKenzie YA, Bowyer RK, Leach H, et al. British Dietetic Association systematic review and evidence-based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). J Hum Nutr Diet 2016;29:549-575. 78. Halmos EP, Power VA, Shepherd SJ, et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 2014;146:67-75 e65. 79. Lacy BE, Pimentel M, Brenner DM, et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol 2021;116:17-44. 80. Ballou S, Keefer L. Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases. Clin Transl Gastroenterol 2017;8:e214. 81. Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 2011;364:22-32. 82. Camilleri M. Bile Acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver 2015;9:332-339. 83. Lembo A, Lacy B, Zuckerman M, et al. Eluxadoline for Irritable Bowel Syndrome with Diarrhea. N Engl J Med 2016;374:242-253. 84. Ford A, Moayyedi P, Chey W, et al. American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome. Am J Gastroenterol 2018;113(Suppl 2):1-18. 85. Rao S, Lembo A, Shiff S, et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012;107:1714-1724. 86. Brenner D, Fogel R, Dorn S, et al. Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials. Am J Gastroenterol 2018;113:735-745. 87. Chey WD, Lembo AJ, Yang Y, et al. Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome With Constipation: A 26- Week, Placebo-Controlled Phase 3 Trial (T3MPO-2). Am J Gastroenterol 2020; Publish Ahead of Print. 88. Chey WD, Lembo AJ, Rosenbaum DP. Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo- Controlled Efficacy and Safety Trial. Am J Gastroenterol 2017;112:763-774. 89. Brenner DM, Sharma A, Patel R, et al. S0517 Efficacy of Plecanatide in Bloated Patients With Chronic Idiopathic Constipation and Moderately to Severely Bloated Patients With Irritable Bowel Syndrome With Constipation. Official journal of the American College of Gastroenterology | ACG 2020;115:S245-S246. 90. Ballou S, Beath A, Kaptchuk TJ, et al. Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation. Clin Gastroenterol Hepatol 2018;16:1738-1744 e1731. 91. Mujagic Z, Keszthelyi D, Aziz Q, et al. Systematic review: instruments to assess abdominal pain in irritable bowel syndrome. Aliment Pharmacol Ther 2015;42:1064-1081. 92. Hawthorn M, Ferrante J, Luchowski E, et al. The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment Pharmacol Ther 1988;2:101-118.