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Impact paragraph 269 A psychological comorbidities on total associated costs and call for a change in quality of care models for IBS. Implementing the biopsychosocial model in healthcare systems could lead to an early recognition of psychological comorbidity in IBS patients, which may further lead to significant economic benefit for the healthcare system and society in general. In addition, this thesis provided the first trial-based data suggesting that treatment with small-intestinal release peppermint oil is cost-effective. This finding can impact clinical decision making, implementing the cost-effective peppermint oil in routine practice and hence lowering total IBS associated costs while high quality care is maintained. Knowledge translation A prerequisite for the implementation of novel scientific knowledge is the dissemination of research findings to the scientific community, healthcare providers, policy makers, and patients. Therefore, the chapters in this thesis were or will be published in international peer-reviewed journals. Moreover, results were presented at various national and international research meetings such as the Dutch Digestive Disease Days, the European NeuroGASTRO meeting, the United European Gastroenterology (UEG) congress, and the Federation of Neurogastroenterology and Motility Meeting. At this moment, the joint multidisciplinary clinical guideline of the Dutch College of General Practitioners (Nederlands Huisartsen Genootschap) and the Dutch society of gastroenterologists (Nederlandse Vereniging van Maag-Darm-Leverartsen) on IBS is under revision. As a result of the studies in this thesis, the novel guideline can incorporate data on prevalence after the change from Rome III to Rome IV diagnostic criteria. Furthermore, based on a meta-analysis that included data from our study 1 , it is expected that peppermint oil will be included as a moderately effective and low-cost first-line treatment option for IBS. Taken together with the publications on the PERSUADE study in Medisch Contact 2 , Nederlands Tijdschrift voor Geneeskunde 3 and Huisarts en Wetenschap 4 , and the publication of trial results by the Maastricht University Medical Center and Zuyderland Medical Center websites and social media accounts, the national dissemination was successful and will likely lead to further implementation throughout the Netherlands. Results of this RCT have been picked up by the international gastroenterologist community as well. Features included an editorial about our study design and results in Gastroenterology 5 , a citation as one of the major highlights of the past decade by the