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Chapter 2 44 23. Ludidi S, Conchillo JM, Keszthelyi D, et al. Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff. Neurogastroenterol Motil 2012;24:729-733, e345-726. 24. Bai T, Xia J, Jiang,Y, et al. Comparison of the Rome IV and Rome III criteria for IBS diagnosis: A cross-sectional survey. J Gastroenterol Hepatol 2017;32:1018-1025. 25. Adeyemo MA, Spiegel BM, Chang L. Meta- analysis: do irritable bowel syndrome symptoms vary between men and women? Aliment Pharmacol Ther 2010;32:738-755. 26. Bjorkman I, Jakobsson Ung E, Ringstrom G, et al. More similarities than differences between men and women with irritable bowel syndrome. Neurogastroenterol Motil 2015;27:796-804. 27. Engsbro AL, Simren M, Bytzer P. The Rome II and Rome III criteria identify the same subtype-populations in irritable bowel syndrome: agreement depends on the method used for symptom report. Neuro- gastroenterol Motil 2012;24: 604-611, e266.