Zsa Zsa Weerts

Contents Chapter 1 General introduction 7 Part I Epidemiological aspects and clinical manifestations of 29 Irritable Bowel Syndrome Chapter 2 Rome III versus Rome IV criteria for irritable bowel 31 syndrome: A comparison of clinical characteristics in a large cohort study Chapter 3 Reduction in IBS symptom severity is not paralleled 49 by improvement in quality of life in patients with irritable bowel syndrome Part II Transient receptor potential channels as therapeutic 71 target Chapter 4 Transient receptor potential channels as possible 73 therapeutic targets in irritable bowel syndrome – a review Chapter 5 A putative anti-inflammatory role for TRPM8 in irritable 103 bowel syndrome – an exploratory study Chapter 6 A novel ileocolonic release peppermint oil capsule for the 121 treatment of irritable bowel syndrome: a pharmacokinetic pilot study in healthy volunteers Chapter 7 Efficacy and safety of peppermint oil in a randomized, 141 double-blind trial of patients with irritable bowel syndrome Chapter 8 A trial-based economic evaluation of peppermint oil for 189 the treatment of irritable bowel syndrome Chapter 9 Smart data collection for the assessment of treatment 211 effects in irritable bowel syndrome: observational study Chapter 10 General discussion 237 Summary 253 Dutch summary 259 Impact paragraph 267 List of publications 273 Acknowledgements 277 Curriculum vitae 285