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Chapter 3 56 patients (assessed by both the GSRS and GSRS-IBS) at follow-up, which was shown on each of the following subdomains: abdominal pain, bloating, diarrhea, constipation, indigestion (all P <0.001), and satiety ( P <0.005). Despite having less GI symptoms, they did not have significantly higher quality of life or more satisfaction with life. Although Rome III- negative patients had significantly less GI-specific anxiety at follow-up ( P <0.001), they did not have less symptoms of general anxiety and depression. Moreover, levels of impaired work productivity and absence from work did not differ between both groups. Table 3.1 Demographical and clinical characteristics, at a five-year follow-up period, of patients who still fulfilled the Rome III criteria for IBS at follow-up (FU Rome III-positive) and those who did not (FU Rome III-negative). Characteristics at follow-up FU Rome III-positive FU Rome III-negative N =112 N =49 Age, median years (IQR) 52 (34-65) 57 (45-67) Female gender, N (%) 84 (75.00) 36 (73.47) BMI, median kg m -2 (IQR) 25.15 (21.88-28.70) 25.35 (21.62-28.37) GSRS, median (IQR) Abdominal pain Reflux syndrome Diarrhea syndrome Constipation syndrome Indigestion syndrome 3.33 (2.67-4.33) 1.50 (1.00-3.00) 3.33 (2.00-4.67) 3.00 (2.00-4.00) 3.75 (2.00-4.67) 2.33 (1.17-3.00) *** 1.50 (1.00-3.00) 1.67 (1.00-3.00) *** 2.00 (1.33-3.00) *** 3.00 (2.25-4.50) *** GSRS-IBS, median (IQR) Abdominal pain Bloating Constipation Diarrhoea Satiety 4.00 (3.5-5.00) 4.33 (3.33-5.00) 2.50 (1.00-4.00) 3.25 (2.25-4.50) 3.00 (2.00-4.50) 2.50 (1.50-3.50) *** 3.00 (2.00-4.33) *** 2.00 (1.00-2.50) 2.00 (1.50-3.00) *** 2.50 (1.25-3.50) ** Comorbid-FD, N (%) 61 (55.00) 20 (41.67) Rome IV-positive IBS, N (%) 69 (61.61) - HADS, score >8, N (%) Depressive symptoms General anxiety symptoms 26 (23.42) 33 (29.72) 8 (16.33) 8 (16.33) GI-specific anxiety, median (IQR) 24.00 (13.00-37.00) 8.00 (4.00-23.00) *** Quality of life, median (IQR) PCS MCS 45.10 (33.01-48.50) 51.27 (37.81-55.96) 48.96 (37.71-52.99) 54.75 (44.61-57.71) Satisfaction with life, N (%) Very unsatisfied Unsatisfied Below average satisfaction Averagely satisfied Satisfied Very satisfied 3 (2.67) 7 (6.25) 20 (17.86) 25 (22.32) 37 (33.04) 20 (17.86) 0 (0.0) 2 (4.08) 4 (8.16) 14 (28.57) 20 (40.82) 9 (18.37) Absence from work, N (%) Impaired productivity at work, N (%) 18 (34.62) 30 (61.22) 6 (25.00) 15 (62.50) N, number of patients included in the analysis; IQR, Inter Quartile Range; BMI, Body Mass Index (kg m -2 ); GSRS, gastrointestinal symptom rating scale; FD, Functional Dyspepsia; HADS, hospital anxiety and depression scale; PCS, physical quality of life composite summary as assessed by SF-36; MCS, mental quality of life composite summary as assessed by SF-36; GI, gastrointestinal. Numbers may not add up to total due to missing. *** P <0.001 versus Rome III-positive; ** P <0.005 versus Rome III-positive.