Zsa Zsa Weerts

IBS symptoms and quality of life 57 3 Baseline - Demographics, clinical characteristics, and symptoms of the Rome III-positive and –negative patients Table 3.2 shows baseline demographics and clinical characteristics (at inclusion time into the cohort) of patients who were Rome III-positive and -negative at follow-up. Table 3.2 Baseline demographical and clinical characteristics, of patients still fulfilling the Rome III criteria for IBS at follow-up (FU Rome III-positive) and those who did not (FU Rome IV-negative). Characteristics at inclusion FU Rome III-positive FU Rome III-negative N =112 N =49 Age, median (IQR) 48 (29-61) 51 (39-61) Gender, N female (%) 84 (75.0) 36 (73.47) BMI, median kg m -2 (IQR) 23.70 (21.50-28.70) 24.40 (21.50-28.05) Secondary/tertiary care, N (%) 72 (64.29) 35 (71.43) IBS subtype, N (%) IBS-D IBS-C IBS-M IBS-U 40 (35.7) 23 (20.5) 47 (42.0) 2 (1.8) 19 (38.8) 8 (16.3) 16 (32.7) 6 (12.2) GSRS, median (IQR) Abdominal pain Reflux syndrome Diarrhea syndrome Constipation syndrome Indigestion syndrome 3.67 (2.33-4.00) 1.50 (1.00-2.63) 3.00 (2.33-4.67) 3.17 (2.33-4.00) 4.25 (3.38-5.00) 2.83 (2.00-3.67) 1.00 (1.00-2.88) 2.83 (1.67-4.25) 1.49 (2.00-3.67) 3.88 (2.75-5.00) Diary, median score (IQR) Discomfort Pain Constipation Diarrhea Bloating Flatulence Belching Nausea 2.29 (2.00-2.72) 2.23 (1.64-2.79) 1.29 (1.00-1.79) 1.21 (1.07-1.64) 2.00 (1.52-2.64) 2.29 (1.89-2.89) 1.36 (1.00-2.00) 1.21 (1.00-1.81) 2.21 (1.64-2.57) 1.93 (1.27-2.50) 1.14 (1.00-1.59) 1.07 (1.00-1.38) 2.00 (1.25-2.43) 2.23 (1.64-2.80) 1.18 (1.00-1.92) 1.14 (1.00-1.57) HADS, score >8, N (%) Depressive symptoms General anxiety symptoms 20 (19.05) 41 (38.68) 6 (5.71) 17 (38.64) Quality of life, median (IQR) PCS MCS 41.71 (33.90-48.98) 50.20 (41.45-55.19) 45.51 (36.32-51.74) 50.67 (41.38-57.44) N, number of patients included in the analysis; IQR, Inter Quartile Range; BMI, Body Mass Index (kg m -2 ); secondary/tertiary care as compared to primary care; GSRS, gastrointestinal symptom rating scale; HADS, hospital anxiety and depression scale; PCS, physical quality of life composite summary as assessed by SF-36; MCS, mental quality of life composite summary as assessed by SF-36. Numbers may not add up to total due to missing. Please note that several variables shown in Table 3.1 derive from questionnaires not administered at baseline and could therefore not be considered in the comparison of baseline variables in Table 3.2 .