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IBS symptoms and quality of life 67 3 Baseline 5 years 0 50 100 % IBS-D IBS-C IBS-M IBS-U No IBS N=161 Baseline 5 years 0 50 100 % N=112 N=161 Supplementary Material Figure S3.1 Proportion of patients with IBS-D, IBS-C, IBS-M, IBS-U, and No IBS (at follow-up) in the total population analyzed, N =161, and the proportion of patients with IBS-D, IBS-C, IBS-M, IBS-U in the population that was Rome III-positive at follow-up, N =112. The figure does not account for transitions of individual patients to different subtypes. N; number, IBS; Irritable Bowel Syndrome. IBS-D; Irritable Bowel Syndrome, diarrhea predominant subtype. IBS-C; Irritable Bowel Syndrome, constipation predominant subtype. IBS-M; Irritable Bowel Syndrome, mixed stool type subtype. IBS-U; Irritable Bowel Syndrome, undefined subtype.