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Chapter 4 98 nociception hypersensitivity. Neurogastroenterol Motil 2009;21:23-32. 25. Schmulson MJ, Valdovinos MA, Milke P. Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 2003;98:1214-1215. 26. Keszthelyi D, Troost FJ, Jonkers DM, et al. Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: a role in pain symptom generation? Eur J Pain 2013;17:1299- 1306. 27. Zhou Q, Yang L, Larson S, et al. Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1. Gut 2016;65:797-805. 28. Xu XJ, Zhang YL, Liu L, et al. Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome: a preliminary explorative study. Aliment Pharmacol Ther 2017;45:100-114. 29. Hughes PA, Brierley SM, Martin CM, et al. TRPV1-expressing sensory fibres and IBS: links with immune function. Gut 2009;58:465-466. 30. Holzer P. TRPV1: a new target for treatment of visceral pain in IBS? Gut 2008;57:882-884. 31. Cenac N, Bautzova T, Le Faouder P, et al. Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. Gastroenterology 2015;149:433-444 e437. 32. Lapointe TK, Basso L, Iftinca MC, et al. TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis. Am J Physiol Gastrointest Liver Physiol 2015;309:G87-99. 33. Barbara G, Stanghellini V, De Giorgio R, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004;126:693-702. 34. Wouters MM, Balemans D, Van Wanrooy S, et al. Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome. Gastroenterology 2016;150:875-887 e879. 35. Zhu L, Zhao L, Qu R, et al. Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine beta-synthetase in a rat model of visceral hypersensitivity. Sci Rep 2015;5:16109. 36. Hong S, Zheng G, Wu X, et al. Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat. Gastroenterology 2011;140:627-637 e624. 37. Hong S, Zheng G, Wiley JW. Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system. Gastroenterology 2015;148:148-157 e147. 38. Khairatkar-Joshi N, Szallasi A. TRPV1 antagonists: the challenges for therapeutic targeting. Trends Mol Med 2009l15:14-22. 39. Fichna J, Poole DP, Veldhuis N, et al. Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. J Mol Med (Berl) 2015;93:1297-1309. 40. Liedtke W, Choe Y, Marti-Renom MA, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 2000;103:525-535. 41. McGuire C, Boundouki G, Hockley JR, et al. Ex vivo study of human visceral nociceptors. Gut 2016; DOI 10.1136/gutjnl-2016-311629. 42. Cenac N, Altier C, Chapman K, et al. Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. Gastroenterology 2008;135:937- 946, 946 e931-932. 43. Sipe WE, Brierley SM, Martin CM, et al. Transient receptor potential vanilloid 4 mediates protease activated receptor 2- induced sensitization of colonic afferent nerves and visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol 2008;294:G1288- 1298. 44. Cenac N, Altier C, Motta JP, et al. Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity. Gut 2010;59:481-488. 45. Cenac N, Andrews CN, Holzhausen M, et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007;117:636-647. 46. Moparthi L, Kichko TI, Eberhardt M, et al. Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity. Sci Rep 2016;6:28763. 47. Cattaruzza F, Spreadbury I, Miranda-Morales M, et al. Transient receptor potential ankyrin-

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