Table of Contents
I
288
Zsa Zsa Weerts
Chapter 1 General introduction
7
Chapter 2 Rome III versus Rome IV criteria for irritable bowel syndrome: A comparison of clinical characteristics in a large cohort study
31
Chapter 3 Reduction in IBS symptom severity is not paralleled by improvement in quality of life in patients with irritable bowel syndrome
49
Chapter 4 Transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome – a review
73
Chapter 5 A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome – an exploratory study
103
Chapter 6 A novel ileocolonic release peppermint oil capsule for the treatment of irritable bowel syndrome: a pharmacokinetic pilot study in healthy volunteers
121
Chapter 7 Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome
141
Chapter 8 A trial-based economic evaluation of peppermint oil for the treatment of irritable bowel syndrome
189
Chapter 9 Smart data collection for the assessment of treatment effects in irritable bowel syndrome: observational study
211
General discussion
237
Summary
253
Dutch summary
259
Impact paragraph
267
List of publications
273
Acknowledgements
277
Curriculum vitae
285
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