Dorien Bangma

FDM IN NEURODEGENERATIVE DISEASES | 79 score in patients with MS (Gerstenecker, Myers, et al., 2017). Goverover et al. (2016) calculated a total money management score based on their FDM performance-based test and a FDM self- report questionnaire and reported that processing speed was the only significant predictor of this total money management score, explaining 18.0% of variance. Influence of age, sex, education, symptoms of depression and disease characteristics in patients with MS. No significant associations were found between FDM and age or education in people living with MS (Tracy et al., 2017). Also no significant associations were found between FDM and symptoms of depression (Gerstenecker, Myers, et al., 2017; Tracy et al., 2017) or anxiety (Goverover et al., 2016) in people living with MS. However, when the impact of motor disabilities on physical functioning in people living with MS increased, as measured with the Timed 25-Foot Walk, poorer performances on ‘basic monetary skills’ of the FCI were observed, although the association was weak (Tracy et al., 2017). Goverover et al. (2016), however, found no significant correlation between FDM and MS disease severity as measured with the Expanded Disability Status Score. Furthermore, group differences regarding FDM between people living with MS and healthy controls remained significant after controlling for upper extremity motor speed (Goverover et al., 2016). Sex in relation to FDM has not been studied in people living with MS. Huntington’s Disease (HD) Only one study (Sheppard et al., 2017; Table 4.2f) investigated FDM in people living with HD and included 20 people living with symptomatic HD with a mild to moderate disease severity (based on the Unified Huntington’s Disease Rating Scale; UHDRS) and compared them with 20 healthy controls. People living with HD had significantly more difficulties with FDM than healthy controls. Furthermore, a significant moderate positive correlation was observed between FDM and global cognition (Table 4.3). More specifically, the Mattis Dementia Rating Scale subtests initiation and perseveration, construction and memory were found to be significantly related to FDM in people living with HD. FDM was, however, not related to disease characteristics of HD (i.e., UHDRS total motor score) nor to symptoms of depression (i.e., Beck Depression Inventory-II and Geriatric Depression Scale short form). The associations between FDM and demographic variables, such as age, sex or education, were not evaluated in people living with HD.