Dorien Bangma

80 | CHAPTER 4 Table 4.2a. Overview of studies measuring financial decision-making in people living with Alzheimer’s disease (k = 25). Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Bassett (1999) USA CS AD (n=20) / Stage: mild/moderate FCQ (total score) - People living with mild/moderate AD showed a significantly lower FDM performance than HC on the FCQ total score. - 55% of people living with mild/moderate AD were classified as incompetent (≤ 2SD below the mean of controls) based on the FCQ total score. AD (mild/moderate) < HC - age (y) 75.3±9.9 - education n.r. - 20.0% male - MMSE 22.0±4.2 - CDR 0.5 to 2.0 HC (n=20) - age (y) 75.2±5.9 - education (y) 13.6±2.4 - 30.0% male - n.r. Clark et al. (2014) + USA LS AD (n=41) / Stage: mild FCI (total score based on domains 1- 7, 9) - 46% (5/11) and 20% (1/5) of people living with mild AD showed significant decline ( ³ 10 points difference) compared to baseline after 1 and 2 years, respectively. - In contrast, 15.8% (6/38) and 17.6% (6/34) of HC showed significant decline (≥10 points difference) compared to baseline after 1 and 2 years, respectively. N/A - age (y) 72.5±6.0 - education (y) 14.0±3.0 - 63.4% male - MMSE 24.3±3.4 * - DRS 119.1±9.7 * HC (n=44) - age (y) 70.5±7.1 - education (y) 14.4±2.2 - 38.6% male - MMSE 29.3±1.2 - DRS 138.9±3.9 Earnst et al. (2001) USA CS AD (n=20) / Stage: mild/moderate FCI (scores on domains 1-7, total score based on domains 1-7) - People living with mild/moderate AD showed significantly lower FDM performances than HC on the FCI total score and on all domains separately. AD (mild/moderate) < HC - age (y) 71.9±7.2 - education (y) 13.3±2.9 - % male n.r. - MMSE 20.5±4.8 ? HC (n=23) - age (y) 71.0±9.2 - education (y) 14.6±1.9 - % male n.r. - MMSE 28.8±0.8 Gerstenecker, Hoagey et al. (2017) + USA CS AD (n=39) / Stage: mild FCI (scores on domains 1-7, total score based on domains 1-7) - People living with mild AD showed significantly lower FDM performances than HC on the FCI total score and on all domains separately. AD (mild) < HC - age (y) 71.3±8.0 - education (y) 14.1±2.6 * - 51.2% male a - MMSE 21.7±5.1 * - DRS 113.9±12.9 * HC (n=60) - age (y) 70.6±7.0 - education (y) 16.0±2.3 - 72.1% male a - MMSE 29.1±1.2 - DRS 138.9±2.8 Gerstenecker et al. (2018) + USA CS AD (n=112) / Stage: mild FCI (scores on 4 domains extracted from factor analyses) - People living with mild AD showed significantly lower FDM performances than HC on all domains. AD (mild) < HC - age (y) n.r. - education (y) n.r. - % male n.r. - n.r. HC (n=179) - age (y) n.r. - education (y) n.r. - % male n.r. - n.r. Table continues on the next page