Dorien Bangma

82 | CHAPTER 4 Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Gill et al. (2019) + Canada ++ CS AD (n=15) / Stage: n.r. FACT (scores on eight domains and total score based on all domains) & FCAI (scores on six domains, total score based on all domains) - People living with AD showed a significantly lower FDM performance than HC on the FACT domain ‘memory’. No group differences were found for the total score and for all other domains. - People living with AD showed a significantly lower FDM performance than HC on the FCAI total score and on all domains separately, with the exception of ‘debt management’. AD ≤ HC - age (y) 77.3±6.4 * - education (y) 14.2±4.4 - 66.7% male ? - MoCA 17.4±4.0 * HC (n=20) - age (y) 67.9±8.9 - education (y) 13.7±2.9 - 40.0% male - MoCA 27.3±1.9 Griffith et al. (2003) + USA CS AD (n=22) / Stage: mild FCI (scores on domains 1-9, total score based on domains 1-7) - People living with mild AD showed significantly lower FDM performances than HC on the FCI total score and on all domains separately, with the exception of ‘assets and estate’. AD (mild) ≤ HC - age (y) 71.5±9.2 - education (y) 14.5±2.5 - 40.1% male - MMSE 24.1±2.6 * - DRS 115.3±11.1 * - CDR 1.0 * HC (n=21) - age (y) 66.7±7.2 - education (y) 14.3±2.7 - 33.3% male - MMSE 29.3±1.0 - DRS 137.4±4.3 - CDR 0.0 or 0.5 Griffith et al. (2007) USA CS AD (n=14) / Stage: mild FCI (total score based on domains 2, 5-7) - People living with mild AD showed a significantly lower FDM performance than HC on the FCI total score. - FDM (total score of the FCI) was mildly to moderately negatively correlated with neural tissue loss or damage (NAA/Cr ratio) and neural demyelination (Cho/Cr ratio). AD (mild) < HC - age (y) 75.9±8.0 - education (y) 15.0±2.8 - 57.1% male - MMSE 25.0±2.5 * - DRS 117.7±10.4 * - CDR 0.5 or 1.0 * HC (n=14) - age (y) 71.0±4.2 - education (y) 14.2±2.2 - 28.6% male - MMSE 29.7±0.5 - DRS 137.9±2.4 - CDR 0 Kershaw & Webber (2008) Australia CS AD (n=22) / Stage: n.r. FCAI (scores on six domains, total score based on all domains) - People living with AD showed significantly lower FDM performances than HC on the FCAI total score and on all domains separately, with the exception of ‘support resources’. The degree of impairment of people living with AD was > 1.5SD below the mean of HC. AD ≤ HC - age (y) 83.0±5.3 * - education (y) ≈ 9 * - 13.6% male ? - MMSE 16.9±4.5 ? HC (n=59) - age (y) 52.5±19.3 - education (y) ≈ 12 - 40.0% male - MMSE 29.6±0.5 Lima-Silva et al. (2015) + Brazil CS AD (n=30) / Stage: n.r. Subscale ‘financial skills’ of DAFS – Brazilian version (total score based on five domains) - People living with AD showed a significantly lower FDM performance than HC on the ‘financial skills’ total score. AD < HC - age (y) 68.7±6.8 - education (y) 8.6±4.5 - 56.7% male - MMSE 19.2±2.3 * - CDR 1.0 HC (n=34) - age (y) 65.4±5.9 - education (y) 9.6±3.9 - 62.8% male - MMSE 25.5±1.3 - CDR n.r. Table continues on the next page