Dorien Bangma

FDM IN NEURODEGENERATIVE DISEASES | 85 Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Stoeckel et al. (2013) USA CS AD (n=16) / Stage: mild FCI (total score based on domains 2, 5-7) - People living with mild AD showed a significantly lower FDM performance than HC on the FCI total score. - FDM was moderately positively correlated with grey matter volumes (MRI) of medial frontal cortex, dorsolateral frontal cortex, precuneus and the angular gyri in people living with mild AD. No significant correlation between grey matter volume (MRI) of hippocampi and FDM was found in people living with mild AD. AD (mild) < HC - age (y) 77.0±8.2 - education (y) 14.3±2.5 - 43.8% male - MMSE 25.1±1.8 * - DRS 118.4±13.2 * - CDR 0.5 or 1.0 * HC (n=16) - age (y) 75.0±4.4 - education (y) 14.3±2.8 - 31.3% male - MMSE 29.4±0.7 - DRS 137.4±2.5 - CDR 0 Tolbert et al. (2019) + USA CS AD (n=20) / Stage: mild FCI – SF (score on 5 domains and total score based on all domains) - People living with mild AD showed a significantly lower FDM performance than HC on the FCI – SF total score and on all domains separately. - FDM was mildly to moderately negatively correlated to ß-amyloid SUVr in people living with mild AD. AD (mild) < HC - age (y) 74.8±6.5 * - education (y) 15.5±2.7 * - 55.0% male - MMSE 24.3±3.6 * - CDR 0.5 or 1.0 ? HC (n=144) - age (y) 71.6±6.2 - education (y) 16.8±2.4 - 48.0% male - MMSE 29.1±1.0 - CDR 0 Table 4.2b. Overview of studies measuring financial decision-making in people living with mild cognitive impairment (k = 26). Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Arcara et al. (2019) Italy CS MCI (n = 40) / Type: n.r. NADL-F test (scores on seven domains) - People living with MCI showed a significantly lower FDM performance than HC on all domains of the NADL-F test, with the exception of ‘reading abilities’, ‘purchase’ and ‘financial judgments’. MCI ≤ HC - age (y) n.r. c - education (y) n.r. c - 50.0% male - n.r. HC (n = 40) - age (y) n.r. c - education (y) n.r. c - 37.5% male - n.r. Bangen et al. (2010) USA CS MCI (n=22) / Type: amnestic Subscale ‘managing money’ of ILS (total score) - People living with amnestic MCI showed significantly lower FDM performances than HC on total score of the ‘managing money’ subscale. - No differences were found between people living with non-amnestic MCI and HC. - No differences were found between people living with amnestic MCI and people living with non-amnestic MCI. MCI (amnestic) < HC MCI (non-amnestic) = HC MCI (amnestic) = MCI (non-amnestic) - age (y) 74.9±7.1 - education (y) 16.5±2.13 - 36.4% male - DRS 49.8±5.7 * MCI (n=16) / Type: non-amnestic - age (y) 77.1±8.5 - education (y) 15.2±3.2 - 62.5% male - DRS 51.3±5.4 * HC (n=82) - age (y) 74.3±9.4 - education (y) 16.0±2.3 - 63.4% male - DRS 55.4±4.5 Table continues on the next page