Dorien Bangma

86 | CHAPTER 4 Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Benavides-Varela et al. (2015) Italy CS MCI (n=33) / Type: n.r. Subscale ‘money usage’ of NADL (total score) - People living with MCI showed a significantly lower FDM performance than HC on the total score of the NADL ‘money usage’ subscale. MCI < HC - age (y) 74.4±6.0 * - education n.r. - 60.6% male - MMSE 26.6±2.5 * HC (n=29) - age (y) 67.1±8.4 - education n.r. - 37.9% male - MMSE 29.1±8.4 Clark et al. (2014) + USA LS MCI converters (n=44) / Type: n.r. FCI (total score based on domains 1- 7, 9) - 35% (15/43) and 32% (11/34) of MCI converters showed significant decline (≥ 10 points difference) compared to baseline after 1 and 2 years, respectively. - 21% (7/34) and 21% (7/33) of MCI non-converter showed significant decline (≥ 10 points difference) compared to baseline after 1 and 2 years, respectively. - In contrast, 15.8% (6/38) and 17.6% (6/34) of HC showed significant decline (≥10 points difference) compared to baseline after 1 and 2 years, respectively. N/A - age (y) 72.8±6.3 - education (y) 14.6±3.2 - 45.5% male - MMSE 27.2±1.9 ** - DRS 129.0±7.1 ** MCI non-converters (n=36) / Type: n.r. - age (y) 71.5±6.2 - education (y) 14.8±2.9 - 38.9% male - MMSE 28.4±1.7 ** - DRS 133.7±5.8 ** HC (n=44) - age (y) 70.5±7.1 - education (y) 14.4±2.2 - 38.6% male - MMSE 29.3±1.2 - DRS 138.9±3.9 Czaja et al. (2017) USA CS MCI (n=62) / Type: amnestic Subscale ‘money management’ of the UMCFAB (total number of correct answers, total number of errors, and efficiency score) - People living with MCI showed lower FDM performances than HC on all scores. - 40% and 34% of people living with amnestic MCI were classified as impaired (i.e., ≤ 2SD below the mean of controls) based on the ‘total number of correct answers’ and ‘total number of errors’, respectively. MCI (amnestic) < HC - age (y) 75.9±7.7 * - education 14.6±4.0 - 33.0% male - CDR 0.5 HC (n=85) - age (y) 72.0±8.3 - education (y) 14.5±3.2 - 23.0% male - CDR 0 Duke Han et al. (2015) USA CS MCI (n=114) / Type: n.r. Subscale FDM of DMCAT (total score) - People living with MCI showed significantly lower FDM performances than HC on the total score. MCI < HC - age (y) 84.3±6.1 * - education (y) 15.4±3.0 - 30.6% male * - Global cognition z-score -0.3±1.4 e* HC (n=586) - age (y) 81.1±7.8 - education (y) 15.2±3.1 - 22.7% male - Global cognition z-score 0.4±0.4 e Gerstenecker et al. (2016) USA LS MCI (n=51) / Type: n.r. FCI (scores on domains 1-7, 9) - People living with MCI showed a significant deterioration regarding FDM in the domains ‘checkbook management’, ‘bank statement management’, ‘bill payment’ and ‘investment decision-making’. N/A - age (y) 71.0±6.6 - education (y) 14.9±3.3 - 54.9% male - Baseline: - MMSE 27.6±1.9 - DRS 130.9±7.3 - Year 2: - MMSE 25.9±4.2 - DRS 124.8±14.6 - 9 participants converted to AD no HC group Table continues on the next page