Dorien Bangma

90 | CHAPTER 4 Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Pereira, Yassuda et al. (2010) + Brazil CS+LS MCI (n=31) / Type: amnestic / non-amnestic Subscale ‘financial skills’ of DAFS – Brazilian version (total score) - People living with MCI showed a significantly lower FDM performance than HC on the total score of the ‘financial skills’ subscale. - No significant differences were found between MCI subtypes and between MCI converters (n=8, follow-up at 15.7±3.7 months) and non-converters (n=23, follow-up at 17.1±4.1 months). - FDM (total score of the ‘financial skills’ subscale) was moderately negatively correlated with total tau and phospho-Ttau 181 concentrations in cerebrospinal fluid in people living with MCI. MCI (amnestic/non- amnestic) < HC MCI (amnestic) = MCI (non-amnestic) MCI (converters) = MCI (non-converters) - age (y) 72.9±7.0 - education (y) 8.5±5.5 * - 26.0% male ? - MMSE 27.3±2.3 HC (n=32) - age (y) 71.6±5.6 - education (y) 13.3±6.0 - 25.0% male - MMSE 28.8±1.5 Sherod et al. (2009) + USA CS MCI (n=113) / Type: amnestic FCI (total score based on domains 1- 7) - People living with MCI showed a significantly lower FDM performance than HC on the FCI total score. MCI (amnestic) < HC - age (y) 70.3±7.4 * - education (y) 14.6±3.2 - 43.4% male - MMSE 28.1±1.9 * - DRS 130.9±6.4 * - CDR 0 or 0.5 * HC (n=85) - age (y) 67.2±8.2 - education (y) 15.0±2.4 - 35.3% male - MMSE 29.4±0.9 - DRS 138.8±3.3 - CDR 0 or 0.5 Tolbert et al. (2019) + USA CS MCI (n=79) / Type: amnestic FCI – SF (score on 5 domains and total score based on all domains) - People living with MCI showed a significantly lower FDM performance than HC on the FCI – SF total score and on all domains separately, with the exception of ‘mental calculation’. MCI (amnestic) ≤ HC - age (y) 71.4±6.7 - education (y) 16.3±2.8 - 57.0% male - MMSE 27.8±2.4 * - CDR 0 or 0.5 ? HC (n=144) - age (y) 71.6±6.2 - education (y) 16.8±2.4 - 48.0% male - MMSE 29.1±1.0 - CDR 0 Triebel et al. (2009) USA LS MCI converters (n=25) / Type: n.r. FCI (scores on domains 1-7, 9, total score based on domains 1-7, total score based on domains 1-7, 9) - After 1-year follow-up, MCI converters showed significantly steeper deteriorations than HC and MCI non-converters on the FCI total scores and domain ‘checkbook management’. No significant deterioration was observed in HC and MCI non-converters. N/A - age (y) 74.4±6.0 § - education (y) 14.4±3.3 - 44.0% male - MMSE 27.0±1.9 § * - DRS 127.4±5.8 § * - CDR 0.5 * MCI non-converters (n=62) / Type: n.r. - age (y) 68.5±7.5 - education (y) 15.2±2.8 - 45.2% male - MMSE 28.6±1.4 * - DRS 134.2±5.9 * - CDR 0.5 * HC (n=76) - age (y) 66.7±8.5 - education (y) 15.0±2.3 - 36.8% male - MMSE 29.4±1.0 - DRS 138.6±3.4 - CDR 0 Table continues on the next page