Dorien Bangma

FDM IN NEURODEGENERATIVE DISEASES | 93 Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Pirogovsky et al. (2013, 2014) f USA CS PD with MCI (n=41) Subscale ‘finances’ of the UCSD performance-based skills assessment (total score) - When combining both PD groups, people living with PD showed significantly lower FDM performances than HC on the total score of the ‘finances’ subscale. - People living with PD-MCI showed significantly lower FDM performances than HC on the total score of the ‘finances’ subscale. No differences in FDM were found between people living with PD- MCI and people living with PD who were cognitively unaffected and between people living with PD who were cognitively unaffected and HC. PD < HC PD-MCI < HC PD cognitively unimpaired = PD-MCI and HC - age (y) 69.2±7.1 - education (y) 15.8±2.8 ** - 73.2% male - DRS 136.7±4.0 ** - UPDRS 23.1±12.3 - H&Y (median) 2 PD cognitively unaffected (n=56) - age (y) 66.7±7.5 - education (y) 17.1±2.4 - 58.9% male - DRS 140.1±2.9 - UPDRS 25.6±12.3 - H&Y (median) 2 HC (n=47) - age (y) 67.1±8.7 - education (y) 16.4±2.5 - 46.8% male - DRS 140.4±3.6 Table 4.2e. Overview of studies measuring financial decision-making in people living with multiple sclerosis (k = 3). Study Country Design Sample characteristics FDM task (scale) Main outcome Conclusion Gerstenecker, Myers et al. (2017) USA CS MS (n=22) / Type: primary progressive and secondary progressive FCI (scores on domains 1-7, 9, total score based on domains 1-7, 9) - People living with MS showed a significantly lower FDM performance than HC on the FCI total score and on all domains separately, with the exception of ‘financial judgment’ and ‘bill payment’. - In people living with MS, 36.4% were classified as severely impaired (degree of impairment £ 2.5 g ) and 13.6% were classified as mild/moderately impaired (degree of impairment £ 1.5 to > 2.5 g ) based on the FCI total score. MS ≤ HC - age (y) 49.4±8.7 - education (y) 13.6±2.5 - 40.9% male - Global cognition n.r. - Onset MS (y) ³ 5 - EDSS 5.9±1.0 HC (n=18) - age (y) 48.6±8.8 - education (y) 13.8±2.0 - 33.3% male - Global cognition n.r. Goverover et al. (2016) USA CS MS (n=30) / Type: relapsing remitting, primary progressive and secondary progressive Money management skills assessed with a website-based AR test (score on five goal-directed actions, total score on five goal-directed actions) - People living with MS showed a significantly lower FDM performance than HC on the AR test total score. More specifically, people living with MS showed significantly more errors than HC with regard to ‘credit card use’ and ‘performing at an efficient pace’ on the AR test. No group differences between people living with MS and HC were found on the other goal- directed actions. MS ≤ HC - age (y) 47.9±10.6 - education (y) 16.3±2.0 - 23.3% male - Global cognition n.r. - Disease duration (mo) 95.9±53.3 - MSFC (z) -1.3±2.0 HC (n=23) - age (y) 50.0±9.4 - education (y) 16.0±2.3 - 43.5% male - Global cognition n.r. Table continues on the next page