Diederik Hentenaar

39 Biomarkers in crevicular peri-implant fluid Table 3a. Median (IQR) biomarker levels in the healthy implants (HI) and diseased implants at baseline (PI T0) Biomaker (median; [IQR]) Implant status Lum-30sec (pg/ml) HI vs PI T0 Lum-30sec (pg) HI vs PI T0 modConc [pg/μl] HI vs PI T0 Luminex-30sec (pg/ml) p value Luminex-30sec (pg) p value modConc [pg/μl] p value IL-1β HI 390.5 [87.0;555.5] 0.007 29.29 [6.5;41.7] 0.007 45.1 [26.3;121.2] 0.267 PI T0 783.5 [414.0;2607.3] 58.8 [31.1;195.5] 57.9 [38.0;158.9] IL-6 HI 20.3 [10.3;48.9] 0.402 1.54 [0.8;3.7] 0.394 2.2 [ 1.1;3.0] 0.002 PI T0 30.6 [10.6;67.4] 2.3 [0.8;5.1] 1.7 [.8;1.3] TNF-α HI 11.3 [7.8;16.6] 0.133 0.86 [0.6;1.2] 0.162 2.15[1.1;2.96] 0.002 PI T0 13.0 [10.5;20.4] 1.0 [0.8;1.5] 1.1 [0.8;1.33] MCP-1 HI 48.13[26.9;72.9] 0.136 3.64 [2.0;5.5] 0.133 7.4 [1.9;12.0] 0.136 PI T0 58.2 [40.3;92.8] 4.4 [3.0;7.0] 5.2 [2.8;6.6] MIP-1α HI 15.63 [8.8;31.8] 0.109 1.2 [0.7;2.5] 0.081 3.0 [1.8;5.2] 0.001 PI T0 10.8 [7.2;17.9] 0.8 [0.5;1.4] 0.8 [0.5;1.5] MMP-8 HI 20590.2 [13512.4;26929.4] 0.001 1544.25 [1013.4;2019.7] 0.001 3224.6 [1773.3;5627.2] 0.094 PI T0 34829.5 [24145.0;41791.5] 2612.2 [1810.8;3134.4] 1974.7 [1292.1;3895.6] OPG HI 34.3 [19.3;53.0] 0.829 2.55 [1.4;4.0] 0.839 5.5[3.3;9.2] 0.001 PI T0 33.9 [20.3;66.2] 2.5 [1.6;5.0] 2.2[1.3;4.1] G-CSF HI 0.0 [0.0;16.7] 0.680 0.0 [0.0;1.2] 0.667 0 [0.0;1.7] 0.989 PI T0 0.0 [0.0;24.0] 0.0 [0.0;1.8] 0.0 [0.0;1.33] Note: Median (IQR) biomarker levels in the healthy implants (HI) and diseased implants at baseline (PI T0). Luminex™ total amounts per 30-seconds in pg/mL, Luminex™ total amounts in pg per 30-seconds (corrected for 75μl elution) and as modified concentration in [pg/μL] corrected for 75μl elution and PICF volume. Mann–Whitney U test significant outcome p < 0.05. Abbreviation: IQR, interquartile range. 2